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Allergy to wheat

MedGen UID:
181859
•Concept ID:
C0949570
•
Pathologic Function
Synonyms: Allergies, Wheat; Allergy, Wheat; Hypersensitivities, Wheat; Hypersensitivity, Wheat; Wheat Allergies; Wheat Allergy; Wheat Hypersensitivities; Wheat Hypersensitivity
SNOMED CT: Allergy to wheat (420174000)

Definition

Allergic reaction to wheat that is triggered by the immune system. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergy to wheat

Professional guidelines

PubMed

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults.
Kennard L, Thomas I, Rutkowski K, Azzu V, Yong PFK, Kasternow B, Hunter H, Cabdi NMO, Nakonechna A, Wagner A
J Allergy Clin Immunol Pract 2018 Nov-Dec;6(6):1892-1897. Epub 2018 Mar 1 doi: 10.1016/j.jaip.2018.02.013. PMID: 29477569
Antibody reactivity in patients with IgE-mediated wheat allergy to various subunits and fractions of gluten and non-gluten proteins from ω-gliadin-free wheat genotypes.
Skoczowski A, Obtułowicz K, Czarnobilska E, Dyga W, Mazur M, Stawoska I, Waga J
Ann Agric Environ Med 2017 May 11;24(2):229-236. doi: 10.5604/12321966.1233572. PMID: 28664699
Clinical presentation, allergens, and management of wheat allergy.
Quirce S, Boyano-Martínez T, Díaz-Perales A
Expert Rev Clin Immunol 2016;12(5):563-72. Epub 2016 Feb 11 doi: 10.1586/1744666X.2016.1145548. PMID: 26800201

Recent clinical studies

Etiology

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.
Balakireva AV, Zamyatnin AA
Nutrients 2016 Oct 18;8(10) doi: 10.3390/nu8100644. PMID: 27763541Free PMC Article
Clinical presentation, allergens, and management of wheat allergy.
Quirce S, Boyano-Martínez T, Díaz-Perales A
Expert Rev Clin Immunol 2016;12(5):563-72. Epub 2016 Feb 11 doi: 10.1586/1744666X.2016.1145548. PMID: 26800201
Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap.
Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K
Allergy 2014 Oct;69(10):1405-11. Epub 2014 Aug 16 doi: 10.1111/all.12481. PMID: 25040662
Allergens to wheat and related cereals.
Tatham AS, Shewry PR
Clin Exp Allergy 2008 Nov;38(11):1712-26. Epub 2008 Sep 24 doi: 10.1111/j.1365-2222.2008.03101.x. PMID: 18823308

Diagnosis

Allergenic Biomarkers in the Molecular Diagnosis of IgE-Mediated Wheat Allergy.
Preda M, Popescu FD, Vassilopoulou E, Smolinska S
Int J Mol Sci 2024 Jul 27;25(15) doi: 10.3390/ijms25158210. PMID: 39125779Free PMC Article
Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain.
Ruemmele FM
Ann Nutr Metab 2018;73 Suppl 4:39-46. Epub 2019 Feb 19 doi: 10.1159/000493929. PMID: 30783043
Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.
Balakireva AV, Zamyatnin AA
Nutrients 2016 Oct 18;8(10) doi: 10.3390/nu8100644. PMID: 27763541Free PMC Article
Clinical presentation, allergens, and management of wheat allergy.
Quirce S, Boyano-Martínez T, Díaz-Perales A
Expert Rev Clin Immunol 2016;12(5):563-72. Epub 2016 Feb 11 doi: 10.1586/1744666X.2016.1145548. PMID: 26800201

Therapy

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Favorable Prognosis of Wheat Allergy in Adults.
Scibilia J, Rossi Carlo M, Losappio Laura M, Mirone C, Farioli L, Pravettoni V, Pastorello EA
J Investig Allergol Clin Immunol 2019 Apr;29(2):118-123. doi: 10.18176/jiaci.0296. PMID: 31017108
Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain.
Ruemmele FM
Ann Nutr Metab 2018;73 Suppl 4:39-46. Epub 2019 Feb 19 doi: 10.1159/000493929. PMID: 30783043
Food allergen-sensitized CCR9(+) lymphocytes enhance airways allergic inflammation in mice.
Castan L, Cheminant MA, Colas L, Brouard S, Magnan A, Bouchaud G
Allergy 2018 Jul;73(7):1505-1514. Epub 2018 Feb 20 doi: 10.1111/all.13386. PMID: 29315632
Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.
Balakireva AV, Zamyatnin AA
Nutrients 2016 Oct 18;8(10) doi: 10.3390/nu8100644. PMID: 27763541Free PMC Article

Prognosis

Favorable Prognosis of Wheat Allergy in Adults.
Scibilia J, Rossi Carlo M, Losappio Laura M, Mirone C, Farioli L, Pravettoni V, Pastorello EA
J Investig Allergol Clin Immunol 2019 Apr;29(2):118-123. doi: 10.18176/jiaci.0296. PMID: 31017108
A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults.
Kennard L, Thomas I, Rutkowski K, Azzu V, Yong PFK, Kasternow B, Hunter H, Cabdi NMO, Nakonechna A, Wagner A
J Allergy Clin Immunol Pract 2018 Nov-Dec;6(6):1892-1897. Epub 2018 Mar 1 doi: 10.1016/j.jaip.2018.02.013. PMID: 29477569
How much does transgenesis affect wheat allergenicity?: Assessment in two GM lines over-expressing endogenous genes.
Lupi R, Denery-Papini S, Rogniaux H, Lafiandra D, Rizzi C, De Carli M, Moneret-Vautrin DA, Masci S, Larré C
J Proteomics 2013 Mar 27;80:281-91. Epub 2013 Feb 9 doi: 10.1016/j.jprot.2013.01.028. PMID: 23403254
Follow-up of the wheat allergy in children; consequences and outgrowing the allergy.
Mansouri M, Pourpak Z, Mozafari H, Abdollah Gorji F, Shokouhi Shoormasti R
Iran J Allergy Asthma Immunol 2012 Jun;11(2):157-63. PMID: 22761189
The effect of wheat allergy on the course of atopic eczema in patients over 14 years of age.
Celakovská J, Ettlerová K, Ettler K, Vanecková J, Bukac J
Acta Medica (Hradec Kralove) 2011;54(4):157-62. PMID: 22283110

Clinical prediction guides

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Favorable Prognosis of Wheat Allergy in Adults.
Scibilia J, Rossi Carlo M, Losappio Laura M, Mirone C, Farioli L, Pravettoni V, Pastorello EA
J Investig Allergol Clin Immunol 2019 Apr;29(2):118-123. doi: 10.18176/jiaci.0296. PMID: 31017108
Clinical presentation, allergens, and management of wheat allergy.
Quirce S, Boyano-Martínez T, Díaz-Perales A
Expert Rev Clin Immunol 2016;12(5):563-72. Epub 2016 Feb 11 doi: 10.1586/1744666X.2016.1145548. PMID: 26800201
Sensitization and elicitation of an allergic reaction to wheat gliadins in mice.
Bodinier M, Leroy M, Ah-Leung S, Blanc F, Tranquet O, Denery-Papini S, Wal JM, Adel-Patient K
J Agric Food Chem 2009 Feb 25;57(4):1219-25. doi: 10.1021/jf802898u. PMID: 19170508
Wheat flour allergy: an entire diagnostic tool for complex allergy.
Battais F, Richard C, Szustakowski G, Denery-Papini S, Moneret-Vautrin DA, Leduc V, Guérin L
Eur Ann Allergy Clin Immunol 2006 Feb;38(2):59-61. PMID: 16711538

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